DISCOVER THE DPA DIFFERENCE FOR JOINT PAIN

In the fight against joint pain and arthritis we need all the help we can get. So why not choose an Omega-3 with the power of THREE fatty acids instead of just EPA and DHA?

SeaDNA Omega-3 Seal Oil is the place to find this three-powered Omega-3.

Check your Omega-3 supplement: does it have DPA? Chances are it doesn’t. And if it does, not in the quantities you can find in SeaDNA Seal Oil.

DPA (Docosapentaenoic acid) occurs naturally in very few places: Seal Oil and mother’s breast milk are two.  A recent article in Montreal en Santé outlined these benefits.

DPA: A JOINT HEALTH SECRET WEAPON

Damaged vessels can lead to joint problems like arthritis and DPA is a powerful Omega-3 to combat this. Scientists have discovered it takes just 10% of DPA compared to EPA to achieve maximal endothelial migration, a critical function in repairing blood vessels causing inflammation. So even though SeaDNA Omega-3 Seal Oil isn’t highly concentrated like many fish oils on the market, its natural, DPA powered properties are an efficient and effective option.

 

DPA: BOOSTS ALL KEY OMEGA-3’s

DPA can suppress inflammation and reduce muscle and joint pain. Studies have found that bioconversion of DPA in the body increases the level of all key omega-3’s (EPA, DHA and DPA), therefore boosting healthy inflammatory levels. Unlike DPA, EPA only increased the proportions of EPA. DPA can perform wonders, this is another. 

DPA: AN INDICATOR OF JOINT HEALTH

Another way Seal Oil with DPA helps is its relationship with numerous inflammation biomarkers (CRP, TNF-α, IL-6) that appear in the blood when there are problems. Science shows concentrations of DPA in the body are inversely correlated with inflammatory cytokine levels in tissues. To put it simply: less DPA means higher levels of inflammation markers. This clearly suggests DPA is critical in limiting factors leading to inflammation and joint pain.

SEADNA SEAL OIL: DPA AND MUCH MORE

Along with the presence of DPA, SeaDNA Seal Oil is also more efficient and more easily digested than alternatives. The fact the seal is a mammal also means our bodies naturally integrate the Omega-3 content faster. We handle the familiar mammal cellular make-up of seal oil very well, meaning no reflux or annoying disgusting burps. SeaDNA Seal Oil is 100% Canadian from front to back and is of the highest quality. Click here to learn more about the differences between seal oil and fish oil.

SeaDNA offers – along with our traditional softgels – a Lemon-Flavour Seal Oil that has been called the “best-tasting Omega-3” supplement on the market. Its versatility means you can add it to smoothies, juices, or your favourite salad dressing. One teaspoon a day is all you need to help make those inflammation woes a little more manageable.

SeaDNA’s line of Omega-3 products have all been certified as Natural Products by Health Canada and are 100% Canadian sourced and produced. 

To order: boutique.seadna.ca/catalog
For more information: seadna.ca or [email protected]


SOURCES: 

Choi M, JuJ, Suh JS, Park KY, Kim KH. Effects of Omega-3-Rich Harp Seal Oil on the Production of Pro-Inflammatory Cytokines in Mouse Peritoneal Macrophages. Preventive nutrition and food science 2015;20:83-7. 

Gan RW, BemisEA, DemoruelleMK, et al. The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population. Rheumatology(Oxford) 2017;56:2229-36.

Miller, E., Kaur, G., Larsen, A., Loh, S. P., Linderborg, K., Weisinger, H. S., et al. (2013). A short-term n-3 DPA supplementation study in humans. Eur. J. Nutr. 52, 895–904. doi: 10.1007/s00394-012-0396-3

Morin C, Blier PU, Fortin S. Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. ArthritisResTher2015;17:142.

Morin C, Hiram R, Rousseau E, Blier PU, Fortin S. Docosapentaenoic acid monoacylglyceride reduces inflammation and vascular remodeling in experimental pulmonary hypertension. Am J PhysiolHeartCircPhysiol2014;307:H574-86.

Neil J . Mann, et al. Effects of seal oil and tuna-fish oil on platelet parameters and plasma lipid levels in healthy subjects, epub, 2010.

Skulas-Ray AC, Flock MR, Richter CK, Harris WS, West SG, Kris-Etherton PM. RedBlood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-DependentlyIncreasesFollowingn-3 FattyAcid Supplementation. Nutrients2015;7:6390-404.

ToshieKanayasu-Toyoda, et al. Docosapentaenoicacid(22:5, n-3), an elongationmetaboliteof eicosapentaenoicacid(20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro, 1996. 

Wiese DM, Horst SN, Brown CT, et al. SerumFattyAcidsAre CorrelatedwithInflammatoryCytokines in UlcerativeColitis. PLoSOne 2016;11:e0156387.

 

 

 

The Arthritis Fight and SeaDNA Omega-3 Seal Oil

 

Arthritis.

If you are reading this there’s a good chance you or someone you love struggles with it.

According to the Arthritis Society the affliction impacts 1-in-6 Canadians over the age of 15 every single day. That’s 4.6 million people in our country alone. And this number is only expected to increase.

There is no cure for arthritis but there are treatments, things we can do to relieve those stiff and painful joints. Omega-3 fatty acids are one avenue to turn to and we believe SeaDNA Omega-3 Seal Oil is your best and most complete option if you do head down this road.

DPA MAKES THE DIFFERENCE

Most Omega-3’s help the body with Arthritis thanks to two fatty acids called EPA and DHA. SeaDNA Omega-3 Seal Oil however, has THREE fatty acids doing the work: EPA, DHA and DPA.

DPA is a rare fatty acid that seal oil contains naturally in relatively balanced proportion to EPA and DHA. It is only found in high-concentrations in a few places on earth, another being mother’s milk. DPA has not been studied as intensively as EPA and DHA, but the science we do have illustrating the benefits of DPA is striking.

BLOOD VESSEL REPAIR

Damaged blood vessels lead to arthritis symptoms and DPA has been found to be ten times more efficient than EPA at a critical function that combats this: endothelial migration. This process helps vessels clear out problems and begin to be healthier. 

Scientists in Japan discovered it took just 10 percent of the amount of DPA compared to EPA required to achieve maximal endothelial migration. This is a clear indication that DPA has real, tangible benefits for those in the fight against Arthritis.

STOP INFLAMMATION BEFORE IT STARTS

Another way Seal Oil and DPA helps is the way it interacts with proteins called C-reactive (CRP) that show up in the blood when there is inflammation in the body.

A study conducted at Pennsylvania University found that those who had high-levels of CRP had decreased levels of DPA.

This indicates those battling arthritis may benefit from Omega-3 supplementation with DPA and it could lead to less CRP in the blood.

IMPROVE YOUR OMEGA-3/6 RATIO

Quebec-based researcher Caroline Morin and her team have also looked at DPA and found it to be very potent in helping our body restore a healthy Omega-3/6 ratio. As we age, our body naturally shifts to a more Omega-6 heavy diet which can throw things out of whack internally. Adding Omega-3 to our diet is the only way to revert this change.

Morin et al found that DPA monoacylglyceride given in prevention is able to modify the _-3/_-6 ratio, thus providing anti-inflammatory and anti-proliferative properties to DPA metabolites.

This is about as clear a finding you can ask to illustrate DPA can benefit the fight against inflammation.

Now, let us be clear: we are not suggesting that SeaDNA Omega-3 Seal Oil is a miracle drug that will end your arthritis woes overnight. We do strongly believe however, this is a great natural option to help and the science behind DPA does show it might be your best Omega-3 option.

SeaDNA Omega-3 Seal Oil is also natural (never artificially modified like concentrated fish oil), won’t lead to digestion or burping issues, is more easily integrated and absorbed by the body due to the seal being a mammal, and is purified to the highest industry standards.

It is also a sustainable and wonderfully Canadian product.

We encourage everyone that is dealing with arthritis or know someone who is, to try or recommend SeaDNA Omega-3 Seal Oil, or to at least further examine it.

For more information: www.seadna.ca or email us at [email protected]

 

SOURCES:

Ann C. Skulas-Ray, * Michael R. Flock, Chesney K. Richter, William S. Harris, Sheila G. West 1.3 and Penny M. Kris-Etherton., Department of Nutritional Sciences, The Pennsylvania State University, University Park Red Blood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following n-3 Fatty Acid Supplementation, Nutrients (2015).

Calder PC. 2006. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. The American Journal of Clinical Nutrition 83 (Suppl 6): 1505S-1519S.

Caroline Morin, Pierre U Blier, and Samuel Fortin. Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. Arthritis Res Ther. 2015; 17: 142.

Jean-Charles Hogue, Contribution of cholesterol ester transfer protein to the heterogeneity of LDL particles in heterozygous familial hypercholesterolemia. 2004. Master of Science (M.Sc.) Laval University.

Kremer JM, Lawrence DA, Petrillo GF, LL Litts, Mullaly PM, Rynes IR, Stocker RP, Parhami N, Greenstein NS, Fuchs BR, Mathur A, Robinson DR, R Sperling, Bigaouette J. 1995. Effects of high-dose fish rheumatoid arthritis after stopping nonsteroidal anti-inflammatory drugs. Arthritis & Rheumatism 38 (8): 1107-1114.

Kremer, J.M. 2000. n23 Fatty acid supplements in rheumatoid arthritis. Am J Clin Nutr 2000; 71 (suppl): 349S-51S

Lau CS, Morley KD, Belch JJ. 1993. Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients with mild rheumatoid arthritis – a double-blind placebo controlled study. British Journal of Rheumatology 32 (11): 982-989.

MacLean CH, Mojica WA, Morton SC, Pencharz J, Hasenfeld Garland R, Tu W, Newberry SJ, Jungvig LK, Grossman J, Khanna P, Rhodes S, Shekelle P. 2004. Effects of omega-3 fatty acids on lipids and glycemic control in type II diabetes and the metabolic syndrome and on inflammatory bowel disease, rheumatoid arthritis, renal disease, systemic lupus erythematosus, and osteoporosis. Summary, Evidence Report/Technology Assessment No. 89. AHRQ No. 04-E012-2. Rockville (MD): Agency for Healthcare Research and Quality.

Nakamura K, Kariyazono H, Komokata T, Hamada N, Sakata R, Yamada K. 2005. Influence of preoperative administration of ω-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. Nutrition 21(6):639-645

Neil J. Mann, et al. Effects of seal oil and tuna-fish oil on platelet parameters and plasma lipid levels in healthy subjects, epub, 2010.

Olendzki B, Leung K, Van Buskirk S, et al. Treatment of rheumatoid arthritis with marine and botanical oils: influence on serum lipids. Evid Based Complement Alternat Med 201; 2011: 827286.

Toshie Kanayasu-Toyoda, Ikuo Morita, Sei-itsu Murota. Docosapentaenoic acid (22:5, n -3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3) is a potente stimulator of endothelial cell migration on pretreatment in vitro. 54(5):319-25 (1996).

Volker D, Fitzgerald P, Major G, Garg M. 2000. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. The Journal of Rheumatology 27(10):2343-2346.